Nextoxin 100IU – Botulinum Toxin Type A - Nexus Pharma

Pack Size: 1 vial × 100 Units per box
Manufactured By: Nexus Pharma.
Made In: South Korea
Product Type: Botulinum Toxin Type A - Lyophilized Powder for Injection
Purpose: Relaxes targeted facial muscles to soften dynamic wrinkles and lines
Product Name: Nextoxin 100IU
Regulatory Approval: MFDS Korea (Ministry of Food and Drug Safety) approved for export

Nextoxin 100IU is a pharmaceutical-grade Botulinum Toxin Type A formulation manufactured by Nexus Pharma in South Korea. It is produced as a lyophilized powder using advanced vacuum-drying technology, a method that differs from conventional freeze-drying and offers measurable advantages in terms of product stability and purity. The result is a vial with a consistent potency profile, fewer inactive proteins, and a reliably reconstituted solution that behaves predictably across injections.

Where some botulinum toxin products degrade faster or show batch-to-batch inconsistency, Nextoxin is engineered to hold up. The vacuum-drying process retains the structural integrity of the active toxin complex, meaning practitioners get the same clinical response from the first vial and the twentieth. For clinics handling volume, that kind of consistency matters far more than it might seem.

Nextoxin carries MFDS Korea export approval and is manufactured under strict pharmaceutical quality controls at the Nexus Pharma facility in Gyeonggi-do, South Korea. It is intended solely for use by trained medical professionals and is not a consumer product.

Actions

Nextoxin works by blocking the release of acetylcholine at the neuromuscular junction. When injected into a targeted muscle, the toxin binds to presynaptic nerve terminals and prevents the chemical signal that would normally trigger muscle contraction from being sent. The result is a temporary, controlled relaxation of that specific muscle group, without affecting surrounding tissue or motor function in adjacent areas.

In aesthetic applications, this translates into a visible softening of dynamic wrinkles, the lines that form through repeated facial movement such as frowning, squinting, or raising the eyebrows. Because Nextoxin's vacuum-dried formulation maintains a lower inactive protein load, the diffusion profile stays controlled, reducing the risk of spread to unintended muscle groups. Effects are not permanent; the nerve terminal gradually recovers over months, which is why maintenance treatments are required to sustain results.

Ingredients

Clostridium Botulinum Toxin Type A, 100 Units per vial

• Human Serum Albumin, 0.5 mg per vial (stabiliser)
• Sodium Chloride, 0.9 mg per vial (tonicity agent)
• Sterile water for injection, used for reconstitution (not included; to be prepared by practitioner)

Benefits of Nextoxin 100IU

• Produced with vacuum-drying technology for superior stability compared to standard lyophilisation
• Minimal inactive protein content — reduces the risk of antibody formation with repeated use
• Consistent potency across vials, giving practitioners a reliable dosing reference
• Controlled diffusion profile allows precise targeting without spread to adjacent muscles
• Fast onset — clinical muscle relaxation typically visible within 3 to 7 days of injection
• Long-lasting effect with results maintained for 3 to 6 months depending on the treatment area
• MFDS Korea approved for export, confirming regulatory compliance and product authenticity
• Suitable for both aesthetic and therapeutic muscle-related indications
• Trusted by medical practitioners for its predictable, reproducible clinical outcomes

How To Use

1. Reconstitute the lyophilized powder with sterile preservative-free normal saline (0.9% NaCl). The volume used depends on the target area and the practitioner's preferred dilution.
2. Draw up the reconstituted solution into an appropriate syringe using an aseptic technique. Use immediately after reconstitution for best results.
3. Identify injection sites based on the target muscle group. Mark the sites with a skin marker if preferred for precision.
4. Inject intramuscularly or intradermally as required for the indication, using a fine-gauge needle. Apply gentle pressure post-injection to reduce bruising.
5. Advise the patient to stay upright for at least 4 hours after treatment and avoid rubbing or massaging the injected area for 24 hours.
6. Schedule follow-up at 2 weeks to assess muscle response and determine if a touch-up dose is needed. Document dosage used per site for future reference.

Scope of Treatment

• Glabellar lines (frown lines between the eyebrows) primary approved indication
• Forehead horizontal lines
• Crow's feet (lateral canthal lines)
• Bunny lines (nasalis wrinkles on nose bridge)
• Brow lifting micro-dose technique
• Mentalis dimpling (chin puckering correction)
• Masseter reduction for jawline slimming
• Platysmal bands on the neck (Nefertiti lift)
• Hyperhidrosis (excessive sweating) axillary and palmar
• Therapeutic use for muscle spasm or medical muscle-related conditions under clinical supervision

Safety and Storage

• Unopened vials must be stored under refrigeration between 2°C and 8°C. Do not freeze.
• Keep away from direct light and do not expose to heat sources.
• Shelf life: up to 36 months from manufacturing date when stored correctly.
• Once reconstituted, use within 4 hours. Discard any unused portion; do not store reconstituted solution.
• Single-use vial only. Do not pool vials or reuse needles.
• Cold chain must be maintained throughout transport and storage to preserve potency.
• Keep out of reach of children and store in a secure clinical setting.

Who Should Avoid

• Patients with known hypersensitivity to Botulinum Toxin Type A or any excipient in the formulation (human serum albumin, sodium chloride).
• Individuals with a diagnosed neuromuscular transmission disorder such as myasthenia gravis, Lambert-Eaton syndrome, or ALS.
• Patients with active infection, inflammation, or skin compromise at the proposed injection site.
• Treatment for pregnant or breastfeeding women should be deferred until after this period.
• Patients on aminoglycosides or other drugs that interfere with neuromuscular transmission, unless under strict medical supervision.
• Anyone under 18 years of age.
• Non-medical individuals: Nextoxin must not be purchased or administered without proper clinical training and licensure.

5 FAQs

How quickly does Nextoxin take effect after injection?

Initial muscle relaxation typically becomes visible within 3 to 5 days of treatment. The full effect is usually apparent by day 10 to 14. The timeline can vary slightly depending on the dose administered, the individual's muscle mass in the treated area, and the practitioner's injection technique. A follow-up assessment at 2 weeks is standard practice to evaluate the outcome.

What makes Nextoxin different from other Botulinum Toxin Type A products?

The key difference lies in the manufacturing process. Nextoxin uses vacuum-drying rather than standard lyophilisation. This method results in a formulation with better structural preservation of the toxin complex, fewer inactive proteins, and a more stable product with a longer shelf life. For the practitioner, this means more consistent dosing behaviour and a lower theoretical risk of neutralizing antibodies developing with repeated treatments.

How long do the results of Nextoxin last?

In most patients, the aesthetic effect of Nextoxin lasts between 3 and 6 months. High-movement areas such as the forehead and crow's feet may metabolise the product faster than lower-activity zones. Masseter reduction and hyperhidrosis treatments can sometimes last longer. Maintenance sessions are typically scheduled every 3 to 4 months to sustain the result.

Can Nextoxin be combined with dermal fillers or other aesthetic treatments?

Yes, Nextoxin is commonly used alongside hyaluronic acid dermal fillers as part of a full facial rejuvenation plan. Botulinum toxin handles dynamic muscle activity while fillers address volume loss and static lines. When combining treatments in a single session, practitioners typically inject botulinum toxin before filler to allow proper positioning assessment. Combining with laser treatments, peels, or other injectables should be managed carefully with appropriate timing between sessions.

What should patients avoid after receiving Nextoxin treatment?

After treatment, patients should remain upright for at least 4 hours. They should avoid rubbing, massaging, or applying pressure to the injected areas for 24 hours. Strenuous exercise, saunas, and excessive heat exposure should be avoided for the remainder of the treatment day. Alcohol should be avoided for 24 hours as it can increase bruising. Normal activities can typically resume on the same day, though any planned facials or aesthetic procedures near the treated area should be postponed for at least 2 weeks.

Precision muscle control starts with the right formulation.

Order Nextoxin 100IU today and give your clinic the stability, purity, and performance that South Korean pharmaceutical standards deliver.